A Short Note on Genomics of Escherichia coli

Comparative genomics has proven useful in identifying putative virulence factors in bacterial pathogens. Escherichia coli is a major cause of sickness and mortality in humans around the world, yet it can also be found as a companion in the human gastrointestinal system. It has served as a model organism for comparative genomic studies to explore the link between genetic content and virulence potential, has many genomic sequences. However, no comprehensive investigation of its entire "virulome" has been conducted to far with the goal of identifying universal or pathotype-specific vaccine targets. The creation of a pathotype database comprising 107 well-characterized totally sequenced pathogenic and nonpathogenic E. coli strains, which we classified for main Virulence Factors, is described here (VFs).

Author(s):

Akraam Hassan

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