eptospirosis is worldwide zoonosis and considered as re emerging disease. Besides economic losses caused by leptospira to animal pro- duction, its zoonotic character makes it an important public health problem. Seroepidemiological study was conducted by MAT randomly according to season, region and district wise of Andhra Pradesh. A total of 2320 serum samples randomly from apparently healthy ani- mals of cattle, buffaloes, sheep, goats, pigs and dogs and 258 serum samples from clinically suspected cases of both animals and humans were subjected for MAT. Overall seropositivity of 20 percent in appar- ently healthy animals, cattle, sheep, goat and dogs was found to be 19.1% 18.67%, 14.63%, 36.84% and 15.15% respectively. Similarly seropositivity in clinically suspected cases (33.37%) of cattle (28.94%) sheep (21.69%) pigs (50.0%) dogs (31.43%) and humans (61.76%) respectively. High seroprevalence in coastal regions (23.09%) followed by Rayalseema (17.49%) and Telangana (16.30%) was observed. High seropositivity was recorded during north east mansoon (28.29%) followed by south west mansoon (21.45%) and lowest in summer (7.26%).
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